Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional. Brands and generics both contain the same active ingredient(s) and are medically equivalent. Some brands are marketed under different names by the same manufacturing country depending on the country of origin.
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Duphaston (dydrogesterone) is a synthetic version of the naturally-occurring hormone progesterone. The overwhelming majority of its use is by women, but it does occasionally see use in men.
Progesterone plays an important role in menstruation and pregnancy. In simple terms, levels of progesterone increase each month, which prepares the womb for an implanted egg. If pregnancy does not occur, levels of progesterone drop and menstruation occurs. If pregnancy does occur, levels stay relatively high until near birth.
Medications like Duphaston artificially replace progesterone, providing the same benefit when natural progesterone levels are low, due to age, injury, medications, or anything else.
Note that women who have had their uterus removed do not need Duphaston or any other progesterone replacement; it will not provide benefit.
Duphaston has a range of uses, from enabling estrogen use in post-menopausal hormone replacement therapy (HRT) to promoting regular menstruation to promoting fertility.
In treating menstrual issues Duphaston is effective in a number of conditions:
And in promoting fertility or aiding with pregnancy:
Treatment of the above can be quite variable depending on intent; dosage and duration of treatment will need to be individualized according to the condition being treated, hormone levels, age, weight, and numerous other personal variables.
Both men and women sometimes use Duphaston to inhibit powerful sexual urges, particularly when those urges deviate from social norms. The medication suppresses such urges, but will not cure them---they'll likely return when treatment ends.
As mentioned above, Duphaston use will likely be customized to an individual's condition and other variables. That said, standard treatment guidelines are as follows:
If doctor instructions deviate from the guidelines above, doctor instructions should always be followed.
Use of this product during pregnancy is somewhat controversial. Some studies show that too-high levels of progesterone can produce negative effects on unborn babies, particularly female babies, producing masculine attributes like facial hair. Other studies show there is no negative effect from using Duphaston (or similar medications) throughout pregnancy. We are not taking a side, simply presenting information. Ultimately it is a personal choice.
Precautions & Side Effects
Duphaston is well-studied and quite well tolerated, with the majority of patients experiencing no or very mild symptoms. Certain individuals are more likely to have serious adverse reactions, however, and Duphaston use should be avoided in those who have:
Likewise the medication should not be used with certain other medications. Of greatest concern are:
Most patients have only mild side effects, including:
Duphaston can cause liver damage. Symptoms to be alert for include abdominal pain that radiates to the back, loss of appetite, and jaundice.