Quinine Sulfate

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Quinine Sulfate is one of the oldest known antimalarial drugs, with its use dating back hundreds of years. More recently it has additionally been used to treat nighttime leg cramps, though its use for this purpose is controversial in some parts of the world.

There is no certain cure for malaria, which is caused by a parasite transmitted to humans by mosquito bites. Even with treatment malaria may result in severe illness and death. Every effort should be made to take preventative measures against mosquito bites when traveling in an area with malaria, including use of protective clothing, mosquito netting, and mosquito repellents.

Though malaria is most commonly associated with sub-Saharan Africa, it is also found in parts of South America and Asia.

Malaria Treatment with Quinine Sulfate:

To treat malaria, Quinine Sulfate tablets are usually taken every 8 hours for up to 7 days. Dosage may vary depending on patient weight, age and other conditions, but on average 600 mg is considered one dose.

Patients taking any form of quinine should avoid taking antacids containing aluminum or magnesium for 3 hours before or after quinine use, as this will considerably reduce the medication's effectiveness.

This medication should be taken with food to prevent nausea or vomiting. If vomiting does occur within 30 minutes of taking quinine, the dose should be retaken. Between 30 to 60 minutes, a half dose should be taken.

Quinine Sulfate is rarely used as a preventative measure against contracting malaria. Products such as Malarone or Lariam are frequently taken prior to and during trips into malaria zones, providing further protection. Preventative treatments are not 100% effective, however, and there is still a chance of becoming ill with malaria. Mixing antimalarials can be very dangerous -- be sure physicians treating malaria are aware of any other antimalarials recently taken.

Pregnant women are particularly prone to serious illness from malaria. Quinine Sulfate is widely considered the safest antimalarial treatment available for treating malaria in pregnant women.

Quinine Sulfate and Nighttime Leg Cramps:

As mentioned above, Quinine Sulfate use to treat nighttime leg cramps is controversial in some areas. In the USA, for example, the FDA has banned manufacture and sale of the product for this use, claiming risk of severe side effects outweigh any benefits.

In other parts of the world, however, it is commonly used to treat leg cramping and for many patients is the most effective and affordable solution available.

To treat nighttime leg cramps, 200 to 300 mg of Quinine Sulfate is taken immediately before bed. It may be taken as tablets or mixed with fluids, but it is extremely bitter and many patients find it difficult to drink. Either way it begins working quickly, enabling patients to sleep comfortably.

Clients are responsible for understanding and complying with local laws concerning Quinine Sulfate use.


Patients with conditions causing heart arrythmia should not use Quinine Sulfate.

Sometimes allergic reactions will develop in individuals using quinine over time, even if no reaction occurred at the start of use. Symptoms of allergic reaction include:
  • Hives, rash or itching
  • Swelling of lips, eyes and tongue
  • Swelling of throat, difficulty breathing
In case of allergic reaction, stop taking Quinine Sulfate and speak with a physician about alternative treatments.

Side Effects:

There are a number of side effects associated with quinine use, ranging from mild to potentially life-threatening. The more dangerous side effects include pulmonary edema, renal failure, and disrupted heart rhythm.

Quinine Sulfate is also known to interact with certain other prescription and non-prescription medications.

Before using Quinine Sulfate, discuss possible risks with a doctor and read the insert included with the product for the most up-to-date information.

Quinine Sulfate overdose can be very dangerous and warrants immediate medical attention.

Quinine Sulfate

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Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional.

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Quinine Sulfate Reviews

Overall rating:
  • 2020-12-12 01:31:44 EST
    Best thing for leg cramps. Been taking for years and its been a life saver.
  • 2020-07-14 22:57:28 EST
    Only thing that helps with body cramping.
  • 2019-08-17 18:49:40 EST
    I learned about Quinine from a friend who had Malaria, but never bought any it for years. When I started doing fence building in the hot Sun of Florida, I started getting severe cramping. hell, I even drank a couple gallons of water a day. A lady told me to buy Quinine at the drug store, which I did. It worked perfectly. When I heard Q was being taken off the US market I went to a few drug stores and bought them out of all they had at $10 per bottle of 100. I then had a few years worth but eventually ran out. My Heart doc wrote me once but the next time he told me he couldn't and referred me to KIWI. Been with KIWI ever since..Yaaaay KIWI.
  • 2018-09-02 18:25:30 EST
    Great for leg cramps
  • 2017-11-20 11:55:53 EST
    This is the only thing that works to control my night leg cramp. I have been taking this for about 17 years. I have no side effects. It has given me many extra years on my life because I can sleep 7 hours without springing out of bed with terrible pain up to 7 times a night.
  • 2017-10-09 19:15:55 EST
    Age: 65 I been plagued by leg cramps since my early teens, quinine is the only thing that helped. When Doctors couldn't prescribe it any longer I suffered through years of trying anything that claimed it helped leg cramps including products the doctors prescribed. Finally my GP suggested KiwiDrugs and I've been satisfied.
  • 2017-04-18 22:41:16 EST
    great for leg cramps
  • 2016-10-24 12:51:10 EST
  • 2016-04-23 03:11:35 EST
    I awaken two to three times a night due to severe lag cramps, some times its rolls me out of bed and I must fold my legs back for at times up to 4 to 5 minutes, after the fact I feel i have straigned musles and have a hard time perusing my normal rutene the next day so i was refered to you to see about trying out quininne, i dont have a regular pc doctor and im hoping you can help me with these long and restless nights, please refer as soon as possible, thank you
  • 2015-09-18 13:52:19 EST
    I have leg cramps that keep me awake all night long I was prefered to take quinine that the drug works miracles however im having a hard time finding a place to purchase it here in the US and I dont have insurance that I can see a doctor to get this drug perscribed and even if I did the doctores here always want to try you on most ly all different types of other drugs that does not work, I have tried quinine for these issues befor and it worked miricals, can you have one of you on line doctors perscribe some of this quinine Sulfate 300 mg so that I can begain to sleep a bid more at night, Thank You Sincerely Craig
  • 2015-03-26 12:37:10 EST
    First used Quinine for malaria when 12, at 15 started leg cramps and am still useing it when needed for the Legs at 81.
  • 2015-03-03 13:15:54 EST
    I Have used it before it was not available over the counter for leg cramps for over 20 yes without any side effects ...ted a.
  • 2015-02-01 11:31:17 EST
    This is not a medication I take every day. In fact, there can be periods of two or three weeks when I do not need to take it. I have night time leg cramping and it becomes significantly worse in winter when the temp dips close to 10C and lower. Summer time, I rarely have the cramping issue, so a prescript for 100 capsules often can last me an entire year. I have been using this med since I was 12 years old when it was offered as a product called Legatrin by Dr Scholls and could be bought without a prescription.
  • 2014-07-28 20:51:31 EST
    I take it sparingly because s&h is so much but have taken it for years and never ha side effects. Dr. tried getting some for mom for her severe cramps before she passed with no luck. Wish I had a computer back then to get her some quinine.
  • 2014-07-08 18:59:13 EST
    I too have musle cramps, quinine has been the answer for me for twenty years so far. No side effects Jan
  • 2013-12-25 14:36:02 EST
    This has really helped me in preventing leg cramps. I have been using this product with no side effects at all. Now I can sleep through the night. Thank you
  • 2013-11-20 09:23:48 EST
    I have taken Quinine Sulfate for over 8 years. Previously I had a clot in my left leg and the Doctor prescribed Quinine Sulfate for me. I have taken it ever since for nightime leg cramps and have had no side effects. by Jennie
  • 2013-11-02 17:57:41 EST
    I have Leg cramps and it is the only thing that Works.
  • 2013-10-04 21:30:53 EST
    I have used Qunine for seven years with no side effects. It is the only things that works to stop leg cramps for me. I had a kidney transplant 7 years ago.
  • 2013-08-24 22:19:13 EST
  • 2013-06-28 02:39:34 EST
    As stated by others I have been taking this medicine since the late eighty, and it is nothing short of being a miracle drug. Nothing else has been of any help and not just leg cramps; I have problems with my entire muscle structure. Darrell Morris
  • 2013-05-10 23:08:04 EST
    i am requesting a re-order of Quinine Sulfate 300mgs as i suffer intense leg cramps i have used Quinine Sulfate for many years and it is the only product that helps kind regards Gary
  • 2013-02-08 16:50:18 EST
    I have Myotonia congenita and have been prescribed quinine sulfate in capsules 324 MG. I have taken it for years and in recent times have found it unavailable in the USA. I was purchasing it in bulk amounts of 6 month lots at 60 per month. I was taking 2 a day for more than 20 years as prescribed by a neurosurgeon from Mayfield Neurological in Cincinnati, Ohio, USA. I would like to be able to purchase Quinine again and would appreciate any help in this matter because I am 58 years old and the Myotonia is having more effects on my mobility and the quinine helps to eliminate the effects and gives me relief from pain and the dystrophy. Please contact me soonest. Thank you.
  • 2012-10-30 00:49:49 EST
    I have used quinine sulfate for leg and feet cramps for about fifteen years. Nitetime is unbearable with it. It is the only thing I have found that works. No side effects.
  • 2012-07-04 11:11:27 EST
    I believe in quinine sulfate for leg cramps. I have never had any side effects.
  • 2012-05-24 17:37:44 EST
    Absolutely the best for preventing night leg cramps. I have used it for at least ten years with no side effects. An absolute necessity for anyone suffering these leg cramps,
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