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Questran (cholestyramine) is used in a variety of applications from lowering cholesterol to hastening the elimination of other medications from the body. It is often used as a cholesterol-reducing medication in cases where dietary changes alone have proven unhelpful. 

Though for the most part a remarkably safe treatment, patients with a history of intestinal blockages, diabetes, thyroid disorders, kidney or liver disease, chronic vitamin deficiency or chronic constipation should use with caution and doctor supervision. 

Conditions Treated 

Questran works by binding with bile it encounters in the intestines, preventing its reabsorption. Without treatment the bile would be reabsorbed and ultimately wind up back in the liver, where it would be secreted once again to aid digestion in the intestine. Bile which is not reabsorbed is instead excreted as waste.  

Bile elimination is helpful in a number of conditions: 

  • Lower LDL cholesterol - The liver uses cholesterol to produce bile. When large amounts of bile are already present, being reabsorbed and reused, the liver has little need to extract cholesterol from the blood to make new bile. By forcing the bile to be excreted, the liver has no choice but to remove cholesterol from the blood to make new bile, ultimately lowering cholesterol levels in the blood. 
  • Reduce itching associated with liver failure - When bile is reabsorbed through the intestine it enters the bloodstream, where the liver should extract it in preparation for the next secretion. When the liver is unable to extract bile from the bloodstream, quantities will build up in both the blood and the skin, a condition which produces severe itching. Removing excess bile with Questran will reduce or eliminate the itching. 
  • Reduce diarrhea from excess bile - Bile attracts water, and excess water in the intestine can cause diarrhea. After certain surgeries, such as gallbladder removal or shortening of the small intestine, as well as in some bowel conditions, such as irritable bowel syndrome, bile will collect in relatively large amounts, attracting excess water, which causes chronic diarrhea. Expelling the excess bile will reduce or eliminate the diarrhea. 
Additionally, in some circumstances Questran may be used to aid expulsion of other medications. Most common is leflunomide, a treatment for arthritis, which may linger in the body for years after treatment stops unless flushed out with a medication like Questran. 

Administering Questran 

This medication comes in a powder, either in packets or in a cannister with a measured scoop. Each packet or scoop represents one dose, or 2 grams of medication. Most patients are prescribed 4 to 8 grams per day, though it may be as high as 24 grams. Smaller doses may be taken once daily, but in most cases the total daily amount is split into 2 doses, and occasionally as many as 6. 

Preparation and administration is fairly straightforward:
  • Mix each dose into a non-carbonated beverage or a food with high liquid content, such as soup or applesauce.
  • For each single packet or scoop there should be 2 to 6 ounces of fluid; if taking 2 packets, mix with a minimum of 4 to 12 ounces of fluid.
  • Consume prepared mixture in entirety; do not hold the mixture in the mouth, doing so may cause tooth discoloration. 
  • Brush teeth after each dose to prevent tooth discoloration.
  • Drink plenty of additional fluids to prevent constipation.
  • Do not exceed prescribed dosage, doing so may cause severe constipation.


cholestyramine  Buy Questran 50 Doses - $99.99
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Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional.

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Questran Reviews

Overall rating:
  • 2019-10-09 12:40:34 EST
    I have gotten sick from mold and used this to remove the toxins. This was the only way I could get the medicine on my own, since my Dr. was unable to help me with mold illness. It comes in 5 gm packets of which 4 gms is the active ingredient. I have ordered it many times. Once customs confiscated an order, all other orders arrived normally. I really appreciate having access to this important medicine!
  • 2016-03-18 07:36:43 EST
    It's working great and it arrived earlier than stated. Would buy again!
  • 2015-12-21 20:10:58 EST
    I have had to take this medication for 20 years now and wouldn't last 6 months without it. I have colitis and no gallbladder (too much bile) and this binds the bile together so I can function nearly normal instead of spending my life unable to eat.
  • 2014-09-25 08:41:34 EST
    I have to take Questran every day it works and I could not lead a normal life without it
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