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Nesina (alogliptin) is a dipeptidyl peptidase-4 inhibitor commonly used, along with lifestyle changes such as diet and exercise, in the treatment of Type II diabetes. This medication is also known as Vipidia.

Dipeptidyl peptidase-4 inhibitors block the production of the peptide hormone glucagon, increasing production of hormone incretin, which in turn increases production of insulin and slows stomach emptying time. The result is an overall lowering of blood glucose. In some cases, if used in conjunction with lifestyle changes such as diet and exercise, Nesina may reduce or eliminate the need for supplemental injectable insulin therapy in patients with Type II diabetes.

Nesina is not intended for the treatment of Type I diabetes or ketoacidosis. Ketoacidosis is a medical emergency and should be treated only by a physician.

A Simple & Effective Solution

Nesina offers patients a number of advantages:

  • Assists the pancreas in producing native insulin.
  • May reduce or eliminate the need for injected insulin therapy specifically in cases of Type II diabetes.
  • Can be used with lifestyle or other anti-diabetic medications such as metformin to further reduce blood glucose levels.
  • Administered by tablet, not injection.
  • Discreet and easily portable.

Nesina, particularly when used in conjunction with lifestyle changes, can significantly slow or even halt progression of diabetic symptoms. This leads to an improved quality of life, and quite possibly increased duration as well.

Administration Guidelines

Because the mode of action of Nesina involves the kidneys, dosage is largely dependent upon the preexisting level of kidney function. A physician is best prepared to properly evaluate kidney function with appropriate tests such as blood urea nitrogen and estimated glomerular filtration rate.

Unlike many other anti-diabetic medications, Nesina may be taken regardless of the timing of meals. Nesina is also not known to cause stomach upset or pain like some other anti-diabetic treatments.

The typical starting dose of Nesina is 25 mg per day. A half-dose is typical for patients with moderate kidney impairment, and a quarter dose for those with severe kidney disease. Nesina is available in each of these dosages as a single pill; for best results and convenience patients should order the correct dosage, rather than take multiple smaller doses or attempt to split large-dose tablets.

At any dose, tablets are usually taken just once per day, with or without food as desired. Some improvements in blood glucose are usually noticeable within days of starting treatment, but it may take several months for full benefit to be seen. Blood glucose should be monitored closely at the start of this or any medication that may influence it.

Side Effects & Potential Complications

Most side effects from Nesina are mild and similar to the common cold, including scratchy nose or throat and respiratory symptoms. Since reduction of blood glucose levels is the treatment goal sometimes low blood glucose can result, though this is less likely to occur with Nesina that with sulfonuric medications.

With or without Nesina blood glucose levels of Type II diabetics should be frequently monitored and any serious fluctuations not easily addressed by a patient should be brought to the attention of a physician.

It is quite likely that patients prescribed Nesina will be scheduled for periodic kidney evaluations. A decrease in kidney function has been observed in people taking Nesina, hence the precaution of kidney function specific dosages. It should be noted, however, that comparable rates of decrease in kidney function have also been observed in similar populations not taking Nesina.

Risk of heart disease may be slightly elevated while taking this medication. There is also a slight association with pancreatitis, an inflammation of the pancreas. Patients should be alert for any signs of changes to kidney, pancreatic, or liver function, including but not limited to unexplained pain---particularly severe abdominal pain or abdominal pain that radiates to the back---or changes in urination or bowel movements, such as pale stools. These symptoms warrant medical attention.

There are currently no harmful drug interactions associated with Nesina.


12.5mg alogliptin  Buy Nesina 28 Tablets - $100.97
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Buy Nesina 28 Tablets 12.5mg $100.97 Add
Buy Nesina 28 Tablets 6.25mg $100.97 Add
Buy Nesina 28 Tablets 25mg $100.97 Add

Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional.

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