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Motilium (domperidone) is a dopamine antagonist primarily known for three different functions: 
  • Suppression of nausea and vomiting caused by other medications
  • Stimulation of lactation in nursing mothers
  • Enhancement of gastrointestinal motility
While there are a number of similar medications which may produce equally good results, Motilium does not pass through the blood-brain barrier, resulting in fewer side effects for many patients. 

Mechanism & Uses 

As a dopamine antagonist, Motilium blocks dopamine receptors found in the digestive system and the brain. In the digestive system, this causes the natural contraction and relaxation of the stomach and bowels, which moves solids through the digestive system. In the brain, it interferes with the signals that tell the stomach to expel an irritant, or vomit. Dopamine suppression in the brain also triggers prolactin secretion, which promotes lactation. 

As a nausea suppressant, this medication is usually given in situations where the nausea is caused by a medication, such as chemotherapy or medications used in treating Parkinson's disease. It may also be used during a migraine headache, but in most non-medication causes, such as morning sickness or motion sickness, a milder, alternative treatment will suffice.  

Motilium is used in a range of gastrointestinal disorders, including: 
  • Gastroparesis (delayed emptying of the stomach)
  • Acid reflux disease (also called GERD)
  • Bloating, gas and/or abdominal discomfort
  • Irritable bowel syndrome
  • Gastritis (inflammation of stomach lining)
  • Dyspepsia (impaired digestion)
  • Hiatal hernia (stomach protrudes through diaphragm)
Though not a cure for the above gastrointestinal conditions, Motilium will significantly reduce symptoms associated with them.  

Motilium has been used extensively around the globe as a lactation stimulant, though it may not be formally approved as such in all locations. Regardless, it is a widely-recognized off-label use and many doctors will not hesitate to prescribe it for mothers who are not producing sufficient milk. Even at relatively high dosage strengths there do not appear to be any negative side effects on nursing infants, though, again, as an off-label use there is little formal data to back these claims up. Its effect on unborn babies is unknown. 

Administration & Dosage

Motilium comes in tablets, oral suspension and suppositories. In most respects treatment with Motilium is similar regardless of the condition being treated; it is usually taken 3 to 4 times daily on an empty stomach, 15 to 30 minutes prior to eating. Dosage strength tends to depend on the type of condition as well as individual patient circumstances: 
  • For nausea suppression, 20 mg in each dose, or 60 to 80 mg daily.
  • For gastrointestinal motility, 10 mg in each dose, or 30 to 40 mg daily, though dosage strength may be raised if needed.
  • For stimulating lactation, 10 to 40 mg in each dose, or 30 to 160 mg daily.
Duration of treatment may last from weeks to months or even years, depending on the condition being treated and patient response to treatment. 

Warnings & Side Effects 

As previously mentioned, side effects with this medication are quite rare and, when they do occur, are typically very mild, including dry mouth, heartburn, drowsiness, and swollen breasts. Very rarely serious reactions may be experienced, which call for medical attention: 
  • Rapid or uneven heart rate
  • Severe dizziness or weakness
  • Painful or difficult urination
  • Swelling of face, hands or feet 
Patients with heart or liver disease, brain tumors, abnormal heart rhythms, or issues with bleeding in the stomach or intestines may be at greater risk of serious side effects from using this medication. 


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Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional.

Motilium Reviews

  • 2016-05-16 18:34:07 EST
    I was literally near death due to gastroparesis before I found this drug. It saved my life.
  • 2014-01-27 12:40:21 EST
    I was diagnosed with Gastroparesis in 2005. I also have GERD & IBS and all the remaining disorders mentioned here. Without Domperidone I am very sick with debilitating nausea as well as chest pains. I am so happy that this drug exists and wish that the USA would carry it. It becomes very expensive as insurance will not cover it.
  • 2011-07-20 20:25:48 EST
    I have gasteroparisis and this is a miracle drug for me. I have tried many other drugs in the US that do not work and have many side effects. This is an AMAZING drug and so happy to be able to get it from Express medicine and Guys Pharmacy in New Zealand. Their customer service is top notch and seamless. If only everything in life was this simple. Fast, cost effective, and great results!
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