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Molipaxin (trazodone) is an antidepressant primarily used to treat depression and anxiety. In low doses it is commonly used to treat insomnia. Off-label the medication may be used to help manage obsessive compulsive disorder, alcohol withdrawal, chronic pain, and erectile dysfunction.

Molipaxin can have a powerful sedative effect. Individuals who have significant low energy, chronic fatigue, or psychomotor retardation may not be good candidates for this medication.

Elderly patients may require modified dosing, as this population is at increased risk of serious side effects. Molipaxin is generally not recommended in patients under 18 years old.

What to Expect from Molipaxin

For depression and other psychiatric disorder, Molipaxin begins producing significant effects about 2 to 4 weeks after treatment starts. Most patients experience:

  • More stabilized mood
  • Fewer and milder mood swings
  • Improved focus and control of thoughts
  • Reduced anxiety
  • More interest in activities
  • Improved impulse control

The medication is believed to work by elevating levels of the neurotransmitter serotonin in the brain. Low or imbalanced serotonin levels are associated with depression, anxiety, and a range of other mental disorders, though serotonin is not always the only neurotransmitter involved. Many people aren't aware that serotonin is also important for memory, sexual desire, appetite, digestion, and other factors as well.

For insomnia Molipaxin begins working on the first or second day, though results vary to some extent. Some patients find it works quickly, in about 15 minutes, producing severe drowsiness; others find it produces some drowsiness after 2 or 3 hours, while still others find it doesn't produce drowsiness at all. This variation can even happen within the same individual---it might induce sleep one day, and do nothing the next. For most patients, however, it consistently helps with falling asleep and staying asleep.

Treatment with Molipaxin usually continues for 6 to 9 months.

Treatment Overview

Molipaxin comes in capsules, which should be swallowed whole with or shortly after a meal. A glass of fluid is also recommended.

Capsules are usually taken once or twice per day. If taking it just once per day, it should be taken at bedtime. If twice per day, capsules should be taken morning and evening.

Dosage depends on the condition being treated as well as personal variables, such as age and weight. Other medications and medical conditions may also be taken into consideration.

For depression:

  • Start with 150 mg per day.
  • If needed, dosage may be increased to 300 mg per day.
  • Rarely some individuals take 600 mg per day.
  • Do not exceed 600 mg in 24 hours.

For anxiety:

  • Start with 75 mg per day.
  • If needed, dosage may be increased to 150 or 300 mg per day.
  • Do not exceed 300 mg per day without explicit doctor approval.

For insomnia:

  • Start with 25 mg per day.
  • If needed, dosage may be increased to 50, 75, or 100 mg per day.

When the time comes for treatment with Molipaxin to end, if taken at doses higher than 25 mg dosage should be gradually tapered down over several weeks. A doctor can help develop a discontinuation plan.

Warnings & Interactions

Patients with other major medical conditions may be at increased risk of serious side effects while taking Molipaxin. Discuss risks and warning signs with a doctor before use if there is a history of:

  • Kidney or liver disease
  • Bleeding problems
  • Heart rhythm problems
  • Low blood pressure
  • Glaucoma
  • Heart disease
  • Bipolar disorder

Molipaxin is known to interact with a range of other medications. Speak with a doctor or pharmacist before taking other medications along with this one, including seemingly-innocuous over-the-counter varieties like St. John's wort or non-steroidal anti-inflammatory drugs (NSAIDs).

Like all medications, Molipaxin can cause side effects. Most are mild and not cause for concern, and will often stop occurring as the body adjusts to treatment. Less commonly more serious side effects may develop, which warrant medical attention:

  • Confusion
  • Fast, pounding, or uneven heartbeat
  • Insomnia
  • Painful and/or prolonged erection of the penis
  • Unusual bleeding or bruising
  • Hallucinations
  • Muscle spasms

If pregnancy is discovered during treatment, speak with a doctor about the best course of action. Remember the medication should not stop abruptly.


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Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional.

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