Improves daytime wakefulness in people with uncontrollable sleepiness caused by narcolepsy or sleep apnea. Also used in people who are sleep deprived from working odd hours such as a night shift.

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Modalert (modafinil) is what's called an eugeroic drug, which means it promotes wakefulness, alertness and/or vigilance. It is most commonly used in medical conditions which cause excessive sleepiness during the day, but is also taken short-term when a schedule is disrupted or when it is vital for a person to stay awake and alert while sleep-deprived.

The medication comes in 200 mg tablets, which may be halved or quartered to produce smaller doses of 100 or 50 mg. The most commonly recommended dose is 200 mg per day, though it may vary from 50 to 400 mg.

400 mg should never be exceeded in one day. Modalert should not be used in individuals under 17 years old.

Resolving Chronic Sleepiness

Modalert is most often used when excessive sleepiness is caused by a medical condition, whether as a direct symptom or because the condition causes disrupted sleep. Some commonly-treated conditions include:

• Narcolepsy
• Sleep apnea
• Neurodegenerative disorders
• Delayed sleep phase syndrome
• Chronic fatigue of unknown origin

In these cases, Modalert helps patients feel well-rested, refreshed and alert. Effects are noticeable 30 minutes to an hour after administration, and effects begin to diminish 8 to 15 hours later, allowing for a normal night's sleep.

Treatment is similar in all cases:

• Take 200 mg once daily in the morning.
• Alternatively, take 100 mg in the morning and 100 mg around midday.

The medication is often used long-term when treating chronic medical conditions; it is not unusual for treatment to span months or even years.

Schedule Adjustment

Whether from jet lag, a shift change at work, or any other disruption, Modalert can make the transition to a new schedule much smoother than it otherwise would be. When used short-term, treatment is typically as follows:

• Take 200 mg an hour before before wakefulness is desired.
• Alternatively, take 100 mg an hour before before wakefulness is desired and another 100 mg as-needed every 4 to 8 hours.

As long as the medication is not taken too close to bedtime, Modalert helps patients stay awake through the new day, so sleep will come easy when the new bedtime arrives.

Staying Awake for Long Periods

Modalert has been used successfully by military and law enforcement groups to keep individuals awake, alert, and performing relatively well for over 40 hours at a stretch. While such use might be justified in combat or disaster scenarios, it is not advisable when not strictly necessary; sleep deprivation can cause serious complications.

Treatment can vary widely when Modalert is used to keep a person awake:

• Take 100 to 200 mg every 4 to 8 hours as needed, not exceeding 400 mg in one day.
• Alternatively, take a large dose of 400 mg once per day.

Individuals interested in the medication for this purpose would do best to speak with a doctor about the ideal dosage.

Other Uses

Modalert is also used for other purposes, including as a weight-loss aid, as a cognitive enhancement aid, and as a performance-enhancing doping agent, among other things. As these are generally not approved uses, there are no standard dosage guidelines.

Though not widely popular, the drug also sees some recreational use; for this purpose tablets are typically pulverized and snorted, which may produce brief feelings of euphoria, but which also carries risk of serious side effects.

Warnings & Side Effects

While most people use Modalert with no problems, there is a very small risk it will produce a potentially life-threatening reaction which can effect the skin and liver. Warning signs which call for immediate medical attention include:

• Any unexplained rash or hives
• Sores in the mouth
• Peeling or blistering skin
• Difficulty swallowing or breathing
• Yellowing of skin or eyes (jaundice)
• Dark urine
• High fever

More often side effects are mild and not cause for concern unless severe:

• Nausea
• Vertigo
• Headache
• Difficulty staying asleep
• Diarrhea or constipation
• Loss of appetite
• Taste changes
• Dry mouth or thirst
• Flushing or sweating
• Stiff muscles

Modalert is known to interact with a wide variety of other medications; speak with a doctor or pharmacist before using it with other drugs. It may reduce the effectiveness of hormonal birth control for up to a month after use.