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Depo-Medrol (methylprednisolone) is a corticosteroid useful in a variety of conditions, though it perhaps sees the most use in alleviating joint pain associated with rheumatoid arthritis or osteoarthritis. The medication inhibits the immune system's reaction, alleviating the swelling, itching, pain, redness, and other symptoms associated with an overactive immune system.

Note that this medication is administered by injection. It must be shaken well before using. Unused product can be stored at room temperature.

Depo-Medrol can be used in all ages in emergency situations, though ideally dosage will be modified accordingly.

Routine Use

Depo-Medrol injections can be used to alleviate symptoms of a range of conditions, including:

  • Arthritis
  • Osteoarthritis
  • Some cancers
  • Some eye conditions
  • Blood disorders
  • Skin diseases
  • Intestinal diseases
  • Lung diseases
  • Kidney diseases
  • Immune system disorders

Treatment can vary widely depending on the condition being treated. Injections may be given daily or weekly, with dosage typically ranging from 4 to 80 mg; in some cases dosage may go up to 160 mg. A doctor should determine dosage and will show patients how to administer the medication directly---or as directly as possible---to the affected area.

The medication should always be shaken prior to use. Skin should be cleaned with alcohol prior to use, and syringes should be cleaned with alcohol following administration if they'll be reused. Applying a small dressing and pressure to the injection site will help eliminate bleeding and pain.

If therapy has continued long-term, treatment should not be abruptly ended. A doctor can help come up with a discontinuation plan.

Emergency Use

Depo-Medrol is sometimes used as a rescue injection in case of anaphylaxis or other allergic reactions. It can alleviate symptoms of food allergies, asthma, reactions to medications, and so forth. Basically, if an allergen is provoking a potentially life-threatening response, Depo-Medrol can be utilized, much like an Epi-Pen, assuming rapid medical attention is not an option.

In relatively mild allergic reactions in adults:

  • Administer 10 to 120 mg intramuscularly, depending on the condition.
  • Do not exceed 120 mg doses.

And in relatively mild cases involving children under age 16:

  • Administer 0.11 to 2 mg per kg of body weight intramuscularly.
  • Do not exceed 60 mg doses.

In severe reactions in adults and children:

  • Administer 1 to 2 mg per kg of body weight intramuscularly, up to 125 mg.
  • Do not exceed 125 mg doses for adults or children.

Again, the above is for emergency use, only when medical attention is not available. The medication is better administered intravenously and dosage is best determined by a doctor, if the medication is used at all; for some situations epinephrine will be preferred.


Patients should avoid use of other medications---including recreational ones like alcohol or marijuana---that induce drowsiness or dizziness while taking Depo-Medrol. At a minimum, use caution until effects are known.

Depo-Medrol does weaken the immune system to some extent. Avoid contact with contagious persons, and do not receive vaccinations, immunizations, or skin tests without prior doctor approval. Avoid contact with individuals who have recently received vaccinations.

Corticosteroid use can impact how a person responds to surgery. If the medication is being used long-term, carrying a card or bracelet indicating use is a good idea. If undergoing dental or medical surgery, be sure to inform the physicians that Depo-Medrol is being used, or has been used in the last 12 months.

Though rare, there is a chance Depo-Medrol can negatively impact unborn babies if it's used by the mother. Use during pregnancy should be stopped unless the benefits outweigh the risks.


40mg - 1ML methylprednisolone  Buy Depo-Medrol 1 Ea - $30.34
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Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional.

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