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Avalide

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Co-Aprovel (irbesartan, hydrochlorothiazide) is a combination medication predominantly used to treat high blood pressure. It is typically prescribed to patients who are not responding well to a single treatment, or who will most likely need two medications to control blood pressure.

This product is suitable for patients age 18 and up. It can be used in children, but doctor involvement is needed to determine dosage and to monitor for developing side effects.

Treating Hypertension

Hypertension (high blood pressure) is notorious for being symptom-free until a catastrophic medical event occurs, which often leads to a significantly reduced quality of life or even the end of life. If hypertension is detected it's important to treat it, and it's important to continue treatment for as long as needed---which may be for the remainder of life if other changes aren't adequate to control it.

Co-Aprovel is a potent treatment for hypertension, utilizing two active ingredients:

  • Irbesartan is an angiotensin II receptor antagonist which, among other things, widens blood vessels. This allows for increased blood flow, lowers blood pressure, and reduces the heart's workload.
  • Hydrochlorothiazide (HCTZ) is a thiazide diuretic, which eliminates salt and water from the body through urine. This reduces overall blood volume and lowers blood pressure.

Each of the above ingredients is an anti-hypertension treatment in its own right; the two are given in combination only when a single treatment does not provide adequate control. Occasionally Co-Aprovel may be the first medication tried; in these cases, a doctor has decided that a singe medication is unlikely to provide adequate control.

Lifestyle changes are usually also recommended, though there are numerous reasons lifestyle changes may not be sufficient to manage high blood pressure, or the patient is unable to make or maintain such changes. In these cases Co-Aprovel, or a similar hypertension treatment, will most likely be taken for the rest of a patient's life.

Dosage & Administration

Co-Aprovel comes in tablets, taken once per day with or without food as desired. Tablets should be swallowed whole and not be crushed, split, or chewed.

The medication comes in three strengths:

  • 150/12.5 mg irbesartan/hydrochlorothiazide
  • 300/12.5 mg irbesartan/hydrochlorothiazide
  • 300/25 mg irbesartan/hydrochlorothiazide

If starting hypertension therapy for the first time:

  • Most patients are started on 150/12.5 mg irbesartan/hydrochlorothiazide.
  • After two to four weeks, dosage may be increased to 300/12.5 mg or 300/25 mg, if needed according to patient response.

If already taking either irbesartan or hydrochlorothiazide and changed to Co-Aprovel:

  • Take Co-Aprovel in the same strength as the ingredient already being taken and the lowest dose of the new ingredient.
  • Dosage adjustments may be required after two to four weeks.

If already taking both irbesartan and hydrochlorothiazide and switching to Co-Aprovel for convenience:

  • Take the same dosage amounts in Co-Aprovel, or as close as possible.
  • Dosage adjustments are unlikely to be needed.

It takes two to four weeks of regular treatment for full benefit to be seen, hence the wait time before adjusting dosage. Patients new to Co-Aprovel should wait at least four weeks before judging the medication's effectiveness.

Adverse Effects

Co-Aprovel will lower blood pressure, which may cause patients to feel somewhat tired, weak, and be dizzy when rising from a sitting or laying position. As long as they're not severe these symptoms are normal and should stop occurring in the first few weeks of treatment.

Doctor attention is warranted if experiencing severe tiredness, fainting, and muscle or joint pain.

Rarely more serious side effects develop which call for immediate medical attention:

  • Difficulty or inability to urinate
  • Eye pain or vision changes
  • Confusion
  • Muscle twitching or cramping
  • Skin rash, peeling, or blistering
  • Rapid or uneven heartbeat
  • Severe nausea or vomiting

Co-Aprovel can interact with a range of other medications. Of most concern are:

  • Aliskiren
  • Lithium
  • Colestipol
  • Carbamazepine
  • Cholestyramine
  • NSAIDs
  • Diabetes medications
  • Steroids

Always double-check with a doctor or pharmacist before taking any other medications with Co-Aprovel.

This product is known to cause birth defects and should not be taken by pregnant women. Effects on nursing infants are less clear; discuss risks with a doctor.

Avalide/Co-Aprovel

150mg/12.5mg irbesartan/hctz  Buy Avalide 28 Tablets - $47.33
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Buy Avalide 28 TabletsGeneric 150mg/12.5mg $47.33 Add
Buy Avalide 28 TabletsGeneric 300mg/12.5mg $47.33 Add
Buy Avalide 28 TabletsGeneric 300mg/25mg $50.03 Add
Buy Avalide 28 TabletsBrand 150mg/12.5mg $54.09 Add
Buy Avalide 28 TabletsBrand 300mg/12.5mg $67.61 Add
Buy Avalide 28 TabletsBrand 300mg/25mg $67.61 Add
Buy Avalide 84 TabletsBrand 150mg/12.5mg $119.99 Add
Quality product from India.

Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional.

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