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  • India
  • Mentadem
  • 20mg
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Mentadem - memantine hcl - 20mg - 90 Tablets Namenda/​Mentadem memantine hcl Brand India 20mg 90 Tablets DR $149.99 Add

Medicines have benefits and some have risks. Always read the label and use only as directed. If symptoms persist or you have side effects see your health professional. Brands and generics both contain the same active ingredient(s) and are medically equivalent. Some brands are marketed under different names by the same manufacturing country depending on the country of origin.

Mentadem (memantine hydrochloride) is used in patients suffering moderate to severe Alzheimer's disease. The medication works by helping to protect NMDA receptors in the brain from the neurotransmitter glutamate, improving memory and slowing progression of the disease.

Patients who take Mentadem often experience improvements in:

  • Attention/focus
  • Memory
  • Orientation
  • Routine activities
  • Socializing
  • Speaking/communicating

Results vary depending on many factors, including severity of the condition. Mentadem can add years of improved cognitive ability, but will not work forever---eventually the disease will progress to such an extent that Mentadem no longer provides benefit.

Who Should Not Take Mentadem

Mentadem is approved for moderate to severe Alzheimer's. Extensive studies have not demonstrated any benefit in mild Alzheimer's, though admittedly it can be difficult to tell, particularly when it comes to delaying progression.

Some patients use Mentadem to treat dementia with Lewy bodies (DLB). This use is controversial; some say DLB is worsened with use of the medication, while others say it helps. While this is a common off-label use, patients or their caretakers are advised to do research and discuss risks with a doctor prior to starting treatment.

Patients with vascular dementia do not appear to experience benefit from Mentadem; nor do patients with autism.

The condition should always be verified by a doctor prior to starting treatment; many different conditions can produce very similar symptoms.

Complementary Medications

Mentadem is effective on its own, but it is often enhanced with certain other medications. Most common among these are Aricept or Exelon.

Aricept and Exelon contain different active ingredients, but both work to preserve the neurotransmitter acetylcholine, which helps brain cells communicate with each other. Together with Mentadem the disease can be slowed even further, and cognition may be improved more than with any one medication alone.

Note that Aricept and Exelon are not both used; just one is chosen to complement Mentadem.

Treatment Guidelines

Mentadem comes in tablets. Tablets can be taken with or without food as desired. A glass of fluid is recommended with each dose.

Tablets can be split if needed, and taking two smaller tablets is the equivalent of taking one larger tablet. For example, two 10 mg tablets provides the same benefit as one 20 mg tablet.

In most cases treatment looks like:

  • Patients are started on 5 mg once per day for one week.
  • On week two, take 10 mg once per day.
  • On week three, take 15 mg once per day.
  • On week four, take 20 mg once per day.
  • Do not exceed 20 mg per day without explicit doctor instruction.
  • Treatment may continue for as long as it provides benefit.

Treatment is often just once per day, usually in the morning. At doses over 5 mg some patients find dividing the dose into two smaller doses, taken morning and evening, provide greater benefit.

It will take a few weeks of regular treatment before significant benefit is seen. Likewise if Aricept or Exelon are being taken; it will take a few weeks from the time the medication is started before additional improvements are seen.

Improvements often span years, though there is of course some variation between individuals. During this time patients often retain their sense of self, are more aware of the present, are able to speak coherently with others, can perform routine tasks unaided, and so forth. As time goes on these benefits will gradually degrade. At some point it will be determined that Mentadem will no longer provide benefit, and treatment will likely end.

Precautions & Adverse Effects

Doctor instructions may deviate from the above treatment guidelines. Always follow doctor instructions, as a doctor can take into account other variables, such as weight, other medications being taken, other medical conditions present, and so forth.

Elderly patients (over age 65) are more susceptible to side effects from Mentadem. Additionally these patients often have at least one other medical condition that further increases risk of side effects. These patients may need close monitoring at the start of treatment until tolerance is established.

When Mentadem is used as directed and titrated over several weeks, serious complications are rare. They can happen, however; the following warrant medical attention:

  • Visual, auditory, or tactile hallucinations
  • Severe confusion
  • Severe mood swings
  • Agitation or aggression
  • Seizures

Mentadem is known to interact with some other medications, including over-the-counter varieties. While these interactions are not always immediately serious, they can degrade effectiveness over time. Always check with a doctor or pharmacist before mixing medications.

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